Lead Bioinformatician

TITLE: Lead Bioinformatician

LOCATION: Cambridge, UK or BioCity Glasgow

SALARY: Competitive salary and benefits package, relative to qualifications and experience

POSITION SUMMARY

Amphista Therapeutics is a fast-growing biotech and the leading Europe-based Targeted Protein Degradation (TPD) company. Initially founded from the laboratory of Professor Alessio Ciulli (University of Dundee) our team comprises both academic and drug discovery pioneers of the TPD field and a growing R&D team focused on advancing a portfolio of medicines to the clinic using our proprietary next generation TPD technologies. We recently completed an oversubscribed $53M funding round to allow us to advance our portfolio of projects towards the clinic and greatly strengthen the development of our underlying scientific platform.

Amphista’s approaches use completely novel mechanisms to build on all the advantages of TPD while directly addressing the emerging limitations of existing TPD strategies to expand the utility of the field. In particular, we have shown our approach has the potential to be superior to all other TPD approaches (PROTACs, molecular glues etc) through our unique novel mechanisms giving expanded scope, improved druglike properties and reduced tumour resistance potential. We have a range of projects in the discovery phase, initially focused on oncology with potential to expand into other therapy areas including CNS disease & immunology. Amphista R&D is based in our twin research hubs in BioCity Glasgow, and Cambridge, UK from where we also work with a wide range of global collaborators and CROs.

We are seeking a creative, proactive and highly-motivated Lead Bioinformatician to join our multi-disciplinary, collaborative team of drug discoverers. In this role, you will be responsible for delivering a range of bioinformatic analyses to support our drug discovery programs ranging from target identification and mode of action studies through to biomarker identification and characterisation of the potential clinical utility of lead candidates.  As a key member of project teams, you will work across our current therapeutic drug discovery projects proactively providing input to define and solve key project questions to allow advancement of the Amphista portfolio. This is an exciting opportunity to join a fast growing and dynamic company operating at the cutting edge of protein degradation to develop first in class medicines to treat cancer and other areas of high unmet medical need.

 

Roles and responsibilities include:

  • Supporting all projects from the Amphista portfolio by provision of high-quality bioinformatic analyses and other input to help projects progress quickly to reach key milestones.
  • Contributing to identification of targets where the proprietary Amphista protein degrading approach is likely to provide high therapeutic benefit to defined cohorts of patients, showing superiority over standards of care.
  • Identification and characterisation of suitable, clinically-relevant cellular systems to build data packages around lead molecules.
  • Analysis of multi-omic data sources in order to build strong supporting datasets around mode of action and selectivity of lead candidates including biomarker strategies.
  • Analysis of a wide variety of bioinformatic data sources including transcriptomics, proteomics, biological network analysis.
  • Working as part of small project teams in an interdisciplinary environment to support research strategies and project goals.
  • Identifying and working with external collaborators to access data sets and additional expertise to contribute to answering key bioinformatic project questions.
  • Contributing to building the wider capability of the Amphista biology & R&D team.
  • Communicating plans and results clearly to programme teams and wider R&D group using a range of verbal and written/electronic routes. Prepare and write-up protocols, methods and reports as required.

 

Essential requirements:

  • PhD in computational biology, genetics or a related discipline with a minimum of 1 year experience working in a multi-disciplinary drug discovery project team setting likely within a pharma or biotech environment.
  • Extensive experience in analysis of large-scale omic data (including genomics, transcriptomics, epigenetics, proteomics) using bioinformatics tools and pipelines including R, Python or similar.
  • Experience in analysing next generation sequencing data & pooled functional genomic screening data (e.g. shRNA, CRISPR) from a range of sources.
  • Accomplished user of medical and biological databases to seek insight into mechanisms of disease
  • Wide experience of applying statistical principles to biological datasets to aid interpretation
  • Good appreciation of where a range of bioinformatic analyses can have the biggest impact on advancing the drug discovery process
  • Ability to work independently, with strong initiative and drive, but also as part of a team to ensure analyses are focused in optimal areas to answer most critical project questions.
  • Excellent ability to communicate through a wide range of verbal, written and electronic means
  • Ability to communicate complex concepts in a clear, interpretable manner to a range of stakeholders including deep experts and non-experts alike eg computational biology experts, scientific programme teams & senior leadership.
  • Must be fun to work with.

 

Experience in the following would be an advantage:

  • A background in human disease genetics, preferably in cancer or rare disease.
  • Familiarity with ubiquitin-proteasome or related cellular biology

 

Applicants should submit a CV and covering letter quoting reference Bix0621 by email to recruitment@amphista.com