Amphista’s Rationally Designed Targeted Glues® - The Next Generation in Targeted Protein Degradation Therapeutics
Our
Mission
Our mission is to unlock the full potential of Targeted Protein Degradation by applying our proprietary Targeted Glue® technology to develop a powerful new generation of transformational medicines.
Our Technology
Unlike therapies that transiently inhibit a single function of a protein associated with disease onset or progression, targeted protein degradation (TPD) medicines are designed to selectively trigger the destruction and removal of specific pathogenic proteins in the body. Historically however, early technology generations of TPD therapeutics have often been constrained by performance limitations associated with their underlying structures and chemical properties.
Amphista’s proprietary next generation TPD technology was specifically designed to address such critical limitations. Our novel degraders function as Targeted Glues® – rationally designed molecules engineered to selectively consolidate key favorable performance characteristics of traditional PROTAC and glue technologies enabling us to target a wider tissue and indication scope than traditional TPD approaches.
Antony Mattessich
Chief Executive Officer
Martin Pass PhD
Chief Development Officer
Louise Modis PhD
Chief Scientific Officer
Giles Brown PhD
Senior VP Chemistry
Our People
Our company ethos revolves around a passion for our science and a deep desire to develop the next generation of rationally designed TPD medicines. We have built a supportive and empowering culture that fosters innovative thinking and learning and encourages all team members to share their talents in building Amphista’s exciting future.
Where we are
Amphista is located on Granta Park, a world-leading technology and biopharmaceutical park in the heart of the vibrant Cambridge, UK biopharma ecosystem, one of the densest biotech centers globally. Being within the ‘golden triangle’ of London, Oxford and Cambridge offers us access to some of the best life sciences talent and expertise globally.