Amphista Therapeutics announces new data demonstrating in vivo efficacy and CNS activity of its mechanistically differentiated targeted protein degraders

  • First demonstration of efficacy in disease-relevant in vivo models for an orally delivered bifunctional non-cereblon / non-VHL-based protein degrader
  • Deep degradation of target protein is achieved in a rapid, sustained, and highly selective manner
  • Successful achievement of efficient CNS delivery for multiple degraders and demonstration of significant degradation of target protein in the brain

Cambridge, UK, January 24th, 2024 – Amphista Therapeutics (“the Company” or “Amphista”), a leader in next generation targeted protein degradation (TPD) approaches, today announces the achievement of two compelling new data sets with its next generation bifunctional degraders demonstrating in vivo efficacy and the ability to target and degrade proteins in the central nervous system (CNS).

Amphista’s degraders, which leverage a novel protein degrading mechanism, with advantages beyond first generation cereblon or VHL-based approaches, have demonstrated:

  • Sustained degradation of target protein and anti-tumor efficacy: once daily oral dosing led to statistically significant reduction in tumor burden and survival advantage in multiple in vivo disease models.
  • Rapid degradation of target protein: significant levels of degradation were induced rapidly after dosing.
  • Highly selective degradation of target protein: statistically significant degradation of target protein vs >8000 other proteins, including closely related homologs, when dosed at 100x DC50.

Amphista also discloses significant progress in the advancement of its technology for the treatment of neurodegenerative diseases, a key focus of the Company. These data show:

  • Amphista degraders can be rationally designed to achieve CNS penetrance with examples achieved across multiple targets.
  • Rapid degradation of target protein achieved in the brain in vivo (dog and non-human primate, and in multiple brain regions) when dosed intravenously.

Louise Modis, Chief Scientific Officer of Amphista Therapeutics, said: “We are delighted by the progress we have made in advancing our pipeline and demonstrating the potential of our unique TPD technology. To our knowledge, this is the first time an orally delivered bifunctional non-cereblon / non-VHL-based protein degrader has shown efficacy in disease-relevant in vivo models. Combined with our progress in demonstrating in vivo degradation of targets within the CNS, we are extremely excited to have achieved these key preclinical development milestones and we look forward to providing additional updates across our pipeline throughout the year.”

Beverley Carr, Interim Chief Executive Officer of Amphista Therapeutics, said: “The last six months have been transformative for Amphista and these new compelling in vivo data strengthen our belief that our technology has the potential to deliver differentiated protein degrader molecules with class-leading physicochemical properties, enabling us to target a wider tissue and indication scope than traditional protein degrader approaches. These data are testament to the strength of our scientific team and we are on track with our portfolio priorities, exploring the tremendous potential of our platform across multiple indications in CNS and oncology.”

About Amphista Therapeutics

Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD). They aim to address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s laboratories at the University of Dundee. The Company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, Eli Lilly & Company and The Dementia Discovery Fund. For more information, please visit: www.amphista.com

Amphista and the Amphista logo are all trademarks of Amphista Therapeutics Limited.

 

For more information please contact:

Amphista Therapeutics 
Beverley Carr, Interim CEO
info@amphista.com

ICR Consilium
Amber Fennell, Namrata Taak
Email: Amphista@consilium-comms.com
Tel: +44 (0)20 3709 5813

 

Amphista Therapeutics Achieves First Milestone in Second Discovery Programme with Bristol Myers Squibb

Cambridge, UK, September 26th, 2023 – Amphista Therapeutics (“the Company” or “Amphista”), a leader in next generation targeted protein degradation (TPD) approaches, today announces it has achieved the first milestone in the second active discovery programme under its strategic collaboration and license agreement with Bristol Myers Squibb (NYSE: BMY), triggering a payment for achieving the milestone.

This follows the announcement of the first milestone achieved in the first discovery programme on May 4, 2023. Both programmes are part of the original agreement with Bristol Myers Squibb, which was announced in May 4, 2022 and included a $30 million upfront payment and the potential for up to $1.25 billion in performance-based milestone payments and payment for a limited expansion of the collaboration, as well as royalties on global net sales of products.

Louise Modis, Chief Scientific Officer of Amphista Therapeutics said: “The achievement of this first milestone in the second discovery programme under Amphista’s strategic collaboration with Bristol Myers Squibb is a testament to our innovative science and ability to discover and progress at pace differentiated, novel therapeutic molecules for our pharmaceutical partners. We have now delivered milestones on both active discovery programmes in our ongoing collaboration with the company and we look forward to continuing this strong momentum. Such collaborations further validate our unique approach and ambition to overcome challenges faced by other target protein degradation modalities. With potential for CNS penetration, we continue to expand the range of potential applications for Amphista’s therapeutic modality.”

Under the agreement, Amphista is responsible for the discovery and development of small molecule protein degraders using EclipsysTM, its next-generation TPD platform. Bristol Myers Squibb is granted a global exclusive license to the resulting degraders and will be responsible for further development and commercialization activities.

 

About Amphista Therapeutics

Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD). They aim to address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s laboratories at the University of Dundee. The Company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, Eli Lilly & Company and The Dementia Discovery Fund. For more information, please visit: www.amphista.com  

 

For more information please contact:

Consilium Strategic Communications
Amber Fennell, Namrata Taak, Stella Lempidaki
Email: Amphista@consilium-comms.com
Tel: +44 (0)20 3709 5813

Amphista Therapeutics Appoints Dr. Giles Brown as Senior Vice President of Chemistry

Highly experienced medicinal chemist joins to further strengthen Amphista’s next generation TPD approach

Cambridge, UK, June 26, 2023 – Amphista Therapeutics (“the Company” or “Amphista”), a leader in next generation targeted protein degradation (TPD) approaches, today announced that Giles Brown, PhD, has been appointed as Senior Vice President (SVP) of Chemistry with immediate effect.

In this role, Giles will work with the leadership team and scientists to advance the Company’s drug discovery pipeline and deliver therapeutic candidates.

He brings over 20 years’ experience in medicinal chemistry during which he contributed to the discovery and development of fifteen preclinical candidates, of which seven successfully entered clinical trials. He joins Amphista from Dunad Therapeutics where he served as Senior Vice President of Chemistry focusing on the discovery of molecular glues. Prior to this, Giles held senior roles at OMass Therapeutics and Sosei Heptares. He holds a PhD from the University of Bristol and his MBA from Henley Business School, UK.

Nicola Thompson, Chief Executive Officer of Amphista Therapeutics said: “Giles is an exceptional chemist and leader with an outstanding track record of drug discovery. His appointment to Amphista reflects the strength of the innovative approach we are taking in TPD to deliver a new generation of therapeutic molecules. We very much look forward to working with Giles to further advance our technology and drug discovery pipeline.”

Giles Brown, Senior Vice President of Chemistry of Amphista Therapeutics, added: “Amphista’s differentiated, next-generation, approach to targeted protein degradation, and its proprietary platform technology, offer a unique opportunity for the discovery of novel, differentiated medicines. I am excited to be joining a team of innovators to advance the Company’s chemistry-led strategy and progress the pipeline to deliver potential medicines for many hard-to-treat diseases.”

About Amphista Therapeutics

Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD). They aim to address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s laboratories at the University of Dundee. The Company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, Eli Lilly & Company and The Dementia Discovery Fund. For more information, please visit: www.amphista.com

For more information please contact:

Amphista Therapeutics
Nicki Thompson, CEO
Email: info@amphista.com

Consilium Strategic Communications
Amber Fennell, Namrata Taak, Stella Lempidaki
Email: Amphista@consilium-comms.com
Tel: +44 (0)20 3709 5813

 

 

Amphista Therapeutics Achieves First Discovery Milestone in Collaboration with Bristol Myers Squibb

CAMBRIDGE, UK, May 4, 2023 – Amphista Therapeutics, a leader in next generation targeted protein degradation (TPD) approaches, today announced the delivery of the first discovery milestone under its collaboration and license agreement with Bristol Myers Squibb, triggering a payment for achieving the milestone.

Nicola Thompson, CEO of Amphista, said, “we are absolutely delighted with the progress and success of our collaboration with BMS. Our ability to deliver our first milestone within the first year of our collaboration exemplifies the strength of our Eclipsys TM platform and our ambition to be a world-leading, next generation protein degradation company.”

The collaboration and license agreement with Bristol Myers Squibb was announced on May 4, 2022 and included a $30 million upfront payment, the potential for up to $1.25 billion in performance-based milestone payments and payment for a limited expansion of the collaboration, as well as royalties on global net sales of products. Amphista is responsible for the discovery and development of small molecule protein degraders using Eclipsys TM, its next-generation TPD platform. Bristol Myers Squibb is granted a global exclusive license to the resulting degraders and will be responsible for further development and commercialization activities.

Amphista’s next generation bifunctional molecules use a novel approach that makes use of a wider range of the body’s own innate protein degrading mechanisms than those used by most other TPD companies. This proprietary approach offers the potential to overcome many of the limitations seen with current TPD approaches, providing the opportunity to treat a wider range of diseases. Amphista is focused on biological targets with a high level of clinical or genetic validation.

About Amphista Therapeutics
Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD). They aim to address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s labs at the University of Dundee. The company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, Eli Lilly & Company and The Dementia Discovery Fund.

Amphista, the Amphista logo and Eclipsys are all trademarks of Amphista Therapeutics Limited.

Media contacts

Lynn Granito
Berry & Company Public Relations
lgranito@berrypr.com
+1 212 253 8881

Amphista Therapeutics Expands Senior Team and Announces Appointment of Louise Modis as Chief Scientific Officer and Ian Churcher as Chief Technology Officer

Cambridge, UK, May 2, 2023 – Amphista Therapeutics, a leader in next generation targeted protein degradation (TPD), today announced that Louise Modis, PhD, has joined the company as Chief Scientific Officer (CSO) and Ian Churcher, DPhil, will transition to the role of Chief Technology Officer (CTO).

In his new role, Ian will focus on leading the continued development of the company’s proprietary degrader platform alongside Louise who will lead drug discovery to further build the company’s portfolio of targeted protein degrader therapeutics.

“Amphista is growing rapidly as we continue to advance our TPD EclipsysTM platform and pipeline. In light of this, we are expanding our senior team with the appointment of Louise. I am delighted that Ian has accepted the role of CTO so he can focus on his depth of expertise in TPD technologies whilst Louise brings a great breadth of experience in advancing drug discovery programs from target identification through to clinical proof-of-concept,” said CEO, Nicola Thompson.

Louise has more than 20 years’ experience in R&D across a range of modalities and therapeutic areas and joins Amphista from the CSO position at Mogrify. Previously, Louise was VP and Discovery Performance Unit head and sponsor of the Immunology Network at GlaxoSmithKline (GSK). Prior to GSK, Louise held scientific leadership roles at Boehringer Ingelheim and Millennium Pharmaceuticals. Louise received her PhD from EMBL in Heidelberg, Germany.

“Amphista has a truly differentiated approach to TPD and I am thrilled to join the company at such an exciting time,” said Louise. “I look forward to working with Ian and the wider team to continue to build the pipeline across different therapy areas.”

Ian said, “The rapid scientific progress we have made means it is the right time to broaden our senior team. I am looking forward to working with Louise as we continue to develop our technology platform and in parallel build our pipeline.”

ENDS

About Amphista Therapeutics
Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD). They aim to address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s labs at the University of Dundee. The company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, Eli Lilly & Company and The Dementia Discovery Fund.

Amphista, the Amphista logo and Eclipsys are all trademarks of Amphista Therapeutics Limited

Media contacts:

Lynn Granito
Berry & Company Public Relations
lgranito@berrypr.com
+1 212 253 8881

Amphista Therapeutics appoints Dr Victoria Lovatt as Vice President of Intellectual Property

Cambridge, UK – January 30, 2023 – Amphista Therapeutics, a leader in next generation targeted protein degradation (TPD) approaches, has announced the appointment of Victoria Lovatt as Vice President of Intellectual Property.

Amphista’s CEO Nicola Thompson said, “I am delighted to welcome Victoria as our Vice President of Intellectual Property. Victoria is an IP strategist who brings a wealth of expertise from her experience working across the globe in the biotech and pharmaceuticals sectors. Victoria’s arrival further strengthens the Amphista team in Cambridge. Her specialist knowledge will support us as we continue our work to unlock the full potential of next generation TPD technology in order to bring transformative medicines to patients.”

Victoria commented on her appointment, “I am delighted to join Amphista’s world class team. Amphista is founded on transformational science and I’m looking forward to building on strong IP foundations to develop a broad strategic IP portfolio as we execute our mission of building the leading TPD company.”

Victoria joins Amphista from Mundipharma where she was Director of IP Strategy. Prior to that, she has held IP roles across the biotechnology and pharmaceuticals industries. Victoria is a Chartered UK Patent Attorney, a European patent attorney and a Singapore patent attorney. She holds a BSc (Hons) from Nottingham University in chemistry/biochemistry and a PhD in neuroimmunology from the University of Cambridge.

– Ends –

About Amphista Therapeutics
Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD) that address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s labs at the University of Dundee. The company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences and Eli Lilly & Company.

For more information, please visit: https://amphista.com/

CONTACTS:

Lynn Granito
Berry & Company Public Relations
lgranito@berrypr.com
212 253 8881

Dementia Discovery Fund invests in Amphista Therapeutics as it targets neurodegenerative diseases

Cambridge, UK – December 13, 2022 – Amphista Therapeutics, a leader in next generation targeted protein degradation (TPD) approaches, today announced a Series B extension investment by the Dementia Discovery Fund (DDF). The investment is in recognition of the progress made in relation to Amphista’s Eclipsys™ platform and its potential to enable therapies to treat diseases of the central nervous system, with a focus on neurodegeneration.

Amphista’s CEO Dr Nicola Thompson said, “This investment from specialist investor DDF will enable us to accelerate the application of our technology into indications largely inaccessible using traditional TPD approaches. It will enable further pre-clinical development with a focus on diseases of the central nervous system, particularly dementia. This additional investment is excellent news and supports our ambition as a world-leading, next generation protein degradation company delivering ground-breaking new medicines to patients in areas of high unmet need.”

Dr Christian Jung, Partner at DDF, said, “Amphista’s Eclipsys™ platform offers impressive differentiation when compared to first-generation protein degradation platforms and enables Amphista to widen its target and indication scope, including in the CNS. We look forward to working with Amphista to support the Company in realising the full potential of their transformational technology, and in delivering disease-modifying therapies in neurodegeneration and beyond.”

Amphista’s next generation bifunctional molecules use a novel approach that makes use of a wider range of the body’s own innate protein degrading mechanisms, instead of the very narrow set of ubiquitin E3 ligase-based mechanisms used by most other TPD companies. This proprietary approach offers the potential to overcome many of the limitations seen with current TPD approaches, providing the opportunity to treat a wider range of diseases. Amphista is focused on biological targets with a high level of clinical or genetic validation, allowing the team to focus on the translation of their novel TPD approach for clinical benefit in areas of high unmet need.

In association with this financing, Amphista has added Dr Christian Jung to the Board.

– Ends –

About Amphista Therapeutics
Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD) that address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s labs at the University of Dundee. The company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, BioMotiv and Eli Lilly & Company.

For more information, please visit: https://amphista.com/

Trademarks: Amphista, the Amphista logo and Eclipsys are all trademarks of Amphista Therapeutics Limited.

About the Dementia Discovery Fund
The Dementia Discovery Fund (DDF) is a specialist venture capital fund, managed by SV Health Managers. DDF invests in, and creates, biotech companies pursuing transformational therapeutic approaches for dementias including Alzheimer’s disease.  DDF’s investment team is responsible for managing more than $475m, using its significant capital and domain expertise to enable talented entrepreneurs to bring therapeutics addressing one of the world’s largest unmet medical needs to the clinic – ultimately aiming to generate significant returns for its investors. DDF is enabled by its networks and influential group of investors including some leading pharmaceutical companies (Biogen, Eli Lilly and Co., GSK, Johnson & Johnson, Otsuka (Astex), Pfizer and Takeda), along with AARP, Aegon, Bill Gates, British Patient Capital, NFL Players Association, Quest Diagnostics, UnitedHealth Group, the UK Government’s Department of Health and Social Care, and the charity Alzheimer’s Research UK. Learn more at www.ddf.vc.

CONTACTS:

Amphista
Lynn Granito
Berry & Company Public Relations
lgranito@berrypr.com
212 253 8881

Dementia Discovery Fund
Tanya Finn
tfinn@svhealthinvestors.com

Fierce Biotech Names Amphista Therapeutics as One of its “Fierce 15” Biotech Companies of 2022

Cambridge, UK – September 12, 2022 – Amphista Therapeutics, a leader in next generation targeted protein degradation (TPD) approaches, today announced that Fierce Biotech has named it as one of 2022’s Fierce 15 biotechnology companies, designating it as one of the most promising early-stage biotechnology companies in the industry.

Amphista is a world leading next-generation Targeted Protein Degradation (TPD) company with the mission to unlock the full therapeutic potential of TPD by addressing the limitations of first-generation approaches. Amphista advantages include: targeting of a non-cereblon component with a more consistent expression profile that enables increased tissue reach, broader disease applicability and potentially greater clinical efficacy. This mechanistic approach, leveraging an essential protein, offers the potential for reduced clinical resistance.  Amphista’s TPD therapeutics are designed to be drug-like molecules with oral bioavailability and the potential for CNS penetration.  Amphista has built a strong IP foundation for the platform including its proprietary warheads, forming the basis of a true platform approach to TPD.

Nicki Thompson, CEO of Amphista, said “We are delighted to be selected as a ‘Fierce 15’ company in a year where we have made outstanding progress in advancing our proprietary Eclipsys™ platform and therapeutic portfolio and in expansion of our world-leading team.  This also comes in a year where our technology has been further recognized and validated by our strategic collaborations with global pharmaceutical companies Merck Healthcare, a division of Merck, and Bristol Myers Squibb worth more than $2 billion.  We remain dedicated to advancing our ground-breaking science with the potential to open up this exciting modality by delivering medicines to patients across a wider range of diseases.”

Every year Fierce Biotech evaluates hundreds of early-stage companies from around the world for its annual Fierce 15 list, which is based on a variety of factors such as the strength of its technology, partnerships, venture backers and a competitive market position.  The Fierce 15 celebrates the spirit of being “fierce” – championing innovation and creativity, even in the face of intense competition.

About Fierce Biotech

Fierce Biotech is the biotech industry’s daily monitor, an email newsletter and web resource providing the latest biotech news, articles, and resources related to clinical trials, drug discovery, FDA approval, FDA regulation, patent news, pharma news, biotech company news and more. More than 450,000 top biotech professionals rely on Fierce Biotech for an insider briefing on the day’s top stories. Signup is free at www.fiercebiotech.com/signup.

About Amphista Therapeutics
Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD) that  address the challenges faced by earlier stage TPD research and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s labs at the University of Dundee. The company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, BioMotiv and Eli Lilly & Company.

For more information, please visit: https://amphista.com/

###

CONTACTS:

Lynn Granito
Berry & Company Public Relations
lgranito@berrypr.com
212 253 8881

Amphista Therapeutics appoints Dr Stuart Wood as VP, Discovery Technology

Cambridge, UK, 7 July 2022 – Amphista Therapeutics, a leader in next generation targeted protein degradation (TPD) approaches, today announced the appointment of Dr Stuart Wood as Vice President of Discovery Technology.

Stuart has held a series of leadership roles in Biotech for over ten years, most recently as Chief Technology Officer at Nanna Therapeutics. Across his roles, Stuart has worked to develop novel solid state nanopore sequencing systems, and applied microfluidic solutions to increase throughput of a range of biochemical and cellular assay systems. More recently at Nanna, Stuart developed a microdroplet screening platform for natural products and medicinal chemistry approaches which underpinned the building of the technology platforms and therapeutic areas at Nanna.

As Nanna grew from two to over twenty staff, Stuart was central to the build of the company and development of early therapeutic programs to tackle mitochondrial dysfunction with application in rare diseases and neurodegeneration in partnership with clinical and academic groups through to the company’s acquisition in 2020 by Astellas.

Stuart began his scientific career working on bacterial genetics & biochemistry studying DNA repair and homologous recombination. He moved to Cambridge to undertake a career development fellowship at the MRC Mitochondrial Biology Unit. Here he studied how errors in mitochondrial DNA replication and transcription led to human disease, developing novel techniques to study mitochondrial nucleic acids.

Amphista’s CSO Dr Ian Churcher said, “On behalf of everyone at Amphista, I am delighted to welcome Stuart to the R&D leadership team. Stuart’s outstanding track record of constant innovation and successful development & application of novel technology strategies to drug discovery projects will enable us to further accelerate the development of Amphista’s next generation Targeted Protein Degradation platform and therapeutic portfolio.”

Amphista’s new VP of Discovery Technology, Dr Stuart Wood, commented on his appointment, “I’m excited to be joining the Amphista team and working alongside many of their pioneers and leaders in the TPD field, an area where there are so many opportunities to apply new technology solutions to the identification and optimisation of new protein degrading drugs. TPD has the potential to deliver transformational medicines and Amphista’s approach promises to overcome many of the limitations now emerging with first generation TPD approaches.”

– Ends –

Media contacts:

Amphista Therapeutics
CEO NicolaThompson
+44 7464 974714
nicki@amphista.com

Berry & Company Public Relations
Doug Haslam
dhaslam@berrypr.com
+1 212 253 8881

About Amphista Therapeutics
Amphista Therapeutics is focused on transforming the lives of patients with severe diseases including cancer. The company is applying its proprietary Amphista degrader platform to advance new approaches in targeted protein degradation (TPD), which address the challenges faced by the field and to realise the full therapeutic potential of this transformational approach. Founded by Advent Life Sciences, Amphista is a spin-out of TPD expert Professor Alessio Ciulli’s labs at the University of Dundee. The company has raised over $60M to date and is funded by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, BioMotiv and Eli Lilly & Company.

For more information, please visit: https://amphista.com/

Amphista Therapeutics Enters Strategic Collaboration with Bristol Myers Squibb for Discovery and Development of Targeted Protein Degradation Therapeutics

  • Amphista and Bristol Myers Squibb to collaborate and leverage Amphista’s proprietary Eclipsys™ targeted protein degradation platform to develop novel protein degrading therapeutics
  • Collaboration includes an upfront payment of $30 million, the potential for up to $1.25 billion in performance-based milestone payments and payments for a limited expansion of the collaboration, as well as royalties on global net sales of products

Cambridge, England, May 4th, 2022 – Amphista Therapeutics, a global leader in the discovery and development of next generation targeted protein degradation (TPD) therapeutics, today announced a strategic collaboration and license agreement with Bristol Myers Squibb.

Under the terms of the agreement, Bristol Myers Squibb and Amphista will work collaboratively to discover and develop small molecule protein degraders.  Bristol Myers Squibb will be granted a global exclusive license to the degraders developed and will be responsible for further development and commercialization activities.  Amphista will receive a $30 million upfront payment, the potential for up to $1.25 billion in performance-based milestone payments and payment for a limited expansion of the collaboration, as well as royalties on global net sales of products. The closing of the transaction is subject to the parties obtaining regulatory clearances or approvals.

Nicola Thompson, CEO of Amphista, said, “Our collaboration with Bristol Myers Squibb is a powerful validation of our advances in TPD research and the capabilities of our Eclipsys next-generation TPD platform.  Combining our expertise with Bristol Myers Squibb’s strong legacy and experience in the protein degradation space brings new promise to the potential of delivering more effective new treatment to patients seeking treatment options.”

TPD therapies are designed to use physiological mechanisms to remove pathogenic protein from the body, offering the potential to access many disease targets previously considered “undruggable.” Amphista’s technology is specifically designed to develop next generation TPD therapeutics based on advanced mechanistic insights and novel chemistry approaches that enable the development of novel protein degrading therapeutics.

“Bristol Myers Squibb continues to build its leadership and scientific expertise in the protein degradation space,” said Rupert Vessey, M.A., B.M., B.Ch., FRCP, D.Phil., Executive Vice President, Research & Early Development, Bristol Myers Squibb. “We look forward to collaborating with Amphista and using its TPD platform to potentially develop new targeted protein degradation therapies.”

About Amphista Therapeutics

Amphista Therapeutics is a global leader in the discovery and development of next generation targeted protein degradation (TPD) medicines, addressing the challenges faced by the field to realise the full potential of this transformational modality.

The company’s proprietary Eclipsys™ Platform supports development of multiple innovative therapeutic candidates able to overcome the limitations associated with traditional TPD approaches with superior levels of efficacy and broad therapeutic applicability. The Amphista team includes pioneers and established leaders in TPD research and all phases of drug discovery and development. The company is supported by leading life science investors including Forbion, Gilde Healthcare, Novartis Venture Fund, Advent Life Sciences, BioMotiv and Eli Lilly & Company.

For more information, please visit: http://www.amphista.com

Media contacts:

Amphista Therapeutics
CEO Nicola Thompson
+44 (0)7436 102411
nicki@amphista.com

Berry & Company Public Relations
Doug Haslam
dhaslam@berrypr.com
+1 212 253 8881